Research Opportunity Letter
Unsolved problems found where medicine meets emerging technology.
Read one opportunity a day, then revisit every issue in the archive. Clinical need and a plausible delivery model come before the technology itself.
Neurorehabilitation · BCI · AI
What if stimulation arrived only when a BCI detected motor intent?
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Retina · Home OCT · AI operations
What if retinal relapse signals could reshape the clinic schedule?
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Parkinson’s · Adaptive DBS · Gait sensing
What if deep brain stimulation could follow the rhythm of gait?
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Cardio-obstetrics · AI stethoscope · Care pathway
What if one prenatal listen could accelerate heart-failure care?
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Type 1 diabetes · Stem-cell islets · AI surveillance
What if transplanted islet cells could signal distress before glucose control fails?
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Cancer survivorship · Wearable neuromodulation · Gait sensing
What if neuromodulation adapted when gait worsened before pain scores did?
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Overactive bladder · Wearable ultrasound · Closed-loop neuromodulation
What if neuromodulation woke only as the bladder filled?
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Cancer survivorship · Home bioimpedance · Compression sensing
What if a home fluid signal called rehabilitation before the arm swelled?
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Hematology · Wearable PPG · Predictive AI
What if tomorrow’s pain crisis appeared on the wrist tonight?
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Colorectal surgery · Smart drain · Predictive AI
What if an anastomotic leak woke the surgical team before sepsis did?
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Rheumatoid arthritis · Vagus stimulation · Treatment-selection AI
What if we knew who should receive neurostimulation before another biologic?
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Lung cancer · Robotic bronchoscopy · Image-guided ablation
What if a lung nodule could be diagnosed and treated in the same procedure?
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Acute kidney injury · Smart catheter · Clinical decision support
What if kidney rescue began in the first 30 minutes of oliguria?
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Glioblastoma · Focused ultrasound · Drug delivery
What if every treatment briefly opened the wall blocking brain-tumor drugs?
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Cervical SCI · Non-invasive spinal stimulation · Sensor AI
What if spinal stimulation adapted each time the hand began to fatigue?
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Epilepsy · Implantable BCI · Conversational AI
What if the brain device asked, “Was that a seizure?”
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Type 2 diabetes · CGM · Behavior and medication AI
What if a 15-day glucose experiment chose the next move?
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Chronic low-back pain · Temporary PNS · Wearable AI
What if nerve stimulation adapted to recovery in movement—not pain scores alone?
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Acute coronary syndrome · Serial ECG · Clinical AI
What if the ECG called for reperfusion before ST elevation crossed the line?
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Burn care · Multispectral imaging · Clinical AI
If we knew today which burns would not heal within 21 days, could we change care and transfer sooner?
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Preventive cardiology · Coronary CT · Inflammation AI
If a coronary artery is not obstructed but inflamed, should prevention change?
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Cancer infusion · Medical robotics · Specimen operations
Could autonomous phlebotomy keep a failed blood draw from delaying cancer treatment?
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CAR-T · Wearables · Home clinical response
Could a wearable bring a CAR-T patient back before the fever becomes obvious?
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Kidney transplant · Organ perfusion · Decision AI
What if a kidney headed for discard got a two-hour second look?
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Maternal care · Handheld ultrasound · AI operations
What if an undated pregnancy did not have to wait for an ultrasound appointment?
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Heart failure · Wearable AI · Subcutaneous diuresis
What if a heart-failure alert reached same-day decongestion—not just a dashboard?
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Type 1 diabetes · Dual biosensing · DKA prevention